Faculty and Research

Development of Non-Viral Vectors for Gene Therapy

Dr. Nejat Düzgünes

Our laboratory has been investigating novel gene transfer vectors that have enhanced stability in the presence of high concentrations of serum and that can be targeted to receptors over-expressed on oral cancer cells.


  • C. Tros de Ilarduya, M.A. Arangoa, M.J. Moreno-Aliaga and N. Düzgünes (2002) Enhanced gene delivery in vitro and in vivo by improved transferrin-lipoplexes. Biochim. Biophys. Acta 1561:209-221.
  • M.A. Arangoa, N. Düzgünes and C. Tros de Ilarduya (2003) Increased receptor-mediated gene delivery to the liver by protamine-enhanced asialofetuin-lipoplexes. Gene Therapy 10:5-14.
  • M. C. Pedroso de Lima, H. Faneca, M. Mano, N. Penaacho, N. Düzgünes and S. Simões (2003) Biophysical characterization of cationic liposome-DNA complexes and their interaction with cells. Methods Enzymol. 373:298-312.
  • C. Tros de Ilarduya, M. A. Arangoa and N. Düzgünes (2003) Transferrin lipoplexes with protamine-condensed DNA for serum-resistant gene delivery. Methods Enzymol. 373:342-356.
  • R. Zhdanov, E. Bogdanenko, A. Moskovtsev, O. Podobed and N. Düzgünes (2003) Liposome-mediated gene delivery: Dependence on lipid structure, glycolipid-mediated targeting and immunological properties. Methods Enzymol. 373:433-465.
  • S. Simões, A. Filipe, H. Faneca, M. Mano, N. Penacho, N. Düzgünes and M.C. Pedroso de Lima (2005) Cationic liposomes for gene delivery. Expert Opin. Drug Deliv 2:237-254.

Dr. Nejat Düzgünes, nduzgune@pacific.edu, 415.929.6565