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Gene Therapy of Oral Cancer via Non-Viral Vectors

Dr. Nejat Düzgünes

We are developing gene therapy methods in which therapeutic genes are targeted specifically to cancer cells, using non-viral gene delivery vehicles ("vectors"). Our current efforts are directed to treating oral squamous cell carcinoma.

References

  • K. Konopka, A. Lee, N. Moser-Kim, S. Saghezchi, A. Kim, A. Lim, V.V. Suzara and N. Düzgünes (2004) Gene transfer to human oral cancer cells via non-viral vectors and HSV-tk/ganciclovir-mediated cytotoxicity: Potential for suicide gene therapy. Gene Ther. Mol. Biol. 8:307-318.
  • K. Konopka, B. Fallah, J. Monzon-Duller, N. Overlid, A. Lim, and N. Düzgünes (2005) Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: Application to HSV-tk/ganciclovir-mediated cytotoxicity. Cell. Mol. Biol Lett. 10:455-470.
  • M. Young, N. Overlid, K. Konopka and N. Düzgünes (2005) Gene therapy for oral cancer: Efficient delivery of a "suicide gene" to murine oral cancer cells in physiological milieu. Calif. Dent. Assoc. J. 33:967-971.
  • K. Konopka, B. Fallah, J. Monzon-Duller, N. 4 , A. Lim, and N. Düzgünes (2006) Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: Application to HSV-tk/ganciclovir-mediated cytotoxicity. Cell. Mol. Biol Lett. 11:171-190.
  • A. Yen, N. Overlid, F. Li, N. Düzgünes and K. Konopka (2007) Survivin promoter-driven gene expression in human oral cancer cells. 85th General Session of the International Association for Dental Research and 36rd Annual Meeting of the American Association for Dental Research, March 21-24, 2007, New Orleans, LA. J. Dent. Res. Vol. 86 (Special issue A) Abstract No. 0758, Seq. #98.
  • C. Spain, N. Overlid, F. Li, N. Düzgünes and K. Konopka (2007) Murine survivin promoter-driven gene expression in cancer and non-tumor cells. 85th General Session of the International Association for Dental Research and 36rd Annual Meeting of the American Association for Dental Research, March 21-24, 2007, New Orleans, LA. J. Dent. Res. Vol. 86 (Special issue A) Abstract No. 2394, Seq. #240.
  • A. Streeter, N. Overlid, K. Konopka and N. Düzgünes (2007) Targeting gene transfer vectors to oral squamous cell carcinoma cells. 85th General Session of the International Association for Dental Research and 36rd Annual Meeting of the American Association for Dental Research, March 21-24, 2007, New Orleans, LA. J. Dent. Res. Vol. 86 (Special issue A) Abstract No. 2586, Seq. #270.
  • S.S. Neves, H. Faneca, S. Bertin, K. Konopka, N. Düzgünes, V. Pierrefite-Carle, S.P. Simões and M. C. Pedroso de Lima (2008) Transferrin-lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in a murine model. Targeting Gene Therapy Symposium, Beyond Genome 2008, San Francisco, CA, June 8-11, 2008.

Contact:
Dr. Dr. Nejat Düzgünes, nduzgune@pacific.edu, 415.929.6565