Physiology

Giuseppe Inesi

Professor of Physiology

Telephone: (415) 929-6657

School of Dentistry
University of the Pacific
2155 Webster Street
San Francisco, CA 94115

Research Interest

Dr Inesi's laboratory is engaged in a long term research project on Molecular and Cellular Aspects of the Ca2+ Transport ATPase. This enzyme is a membrane bound protein that utilizes ATP for active transport of Ca2+, and is required for storage of Ca2+ in intracellular stores. In turn, release of the stored Ca2+ is required for intracellular signaling and initiation of most cellular functions as a second messenger. Ca2+ transport is also involved in bone formation.  Dr Inesi's molecular studies include determination of enzyme and transport kinetics, protein chemistry and derivatization of various amino acid residues, and production of recombinant protein to obtain specific mutations and assess their effects on catalytic and transport function. Cellular studies involve overexpression or silencing of the ATPase gene in cultured cells, and determination of functional consequences with regard to Ca2+ signaling and regulation of Ca2+ dependent functions. Dr Inesi’s laboratory is located at the Research Institue of the California Pacific Medical Center, and his research is currently supported by a five year National Institutes of Health.